From I-40:

Take Exit 390 to Cherry Street. Turn right off the exit and follow Cherry Street for 0.5 miles. Turn right onto Magnolia Avenue. At the next light (Walgreens is on your left), turn left onto Chesnut Street. Continue straight until the street dead ends at Biddle Street. Turn left onto Biddle and take the next right onto Wimpole Avenue. The parking lot will be on your right as you get to the top of the hill. The Visitors Center is past the parking lot on your left.

From Downtown:

Take Summit Hill Drive, east from downtown and cross over James White Parkway. Follow Summit Hill until it becomes Dandridge Avenue, which becomes Brooks Avenue at Wilder Place. Follow Brooks Avenue, turn left on Biddle Street, turn right on Boyd’s Bridge Pike, turn left onto Parish Street, and then left onto Wimpole Avenue. (not as difficult as it sounds ... :) )

Look for Green Garden Signs along your way ...